Back to search
premature ovarian failure
An older clinical term denoting the cessation of ovarian follicular activity before age forty; current international medical consensus strongly recommends replacing this terminology with premature ovarian insufficiency. 
Grammatical category Noun
Field Fertility problems
Level of specialization High
Definition source glosario de Fertilidad
Gender relationship Yes, woman
Variants
Acronym
POF
Formal
Synonym
premature ovarian insufficiency
Formal
Equivalents

Spanish

fallo ovárico prematuro
FOP

Valenciano

fallada ovàrica precoç
Associated concepts
May cause
infertility
Is accompanied by
low oestrogen levels
Examples
It is well known that premature ovarian failure can negatively impact quality of life, causing a variety of climacteric symptoms, urogenital and sexual dysfunctions, emotional disturbances, decreased bone mineral density, and impaired lipid profile.
As a much lower dose, less than 4 Gy, can destroy 50% of immature oocytes, a premature ovarian failure may be expected as a possible consequence of every pelvic radiotherapy if not preceded by ovarian transposition.