Bone marrow-derived stem cells (BMDSCs) Recent studies have shown that there are residual follicles in the ovaries of POI patients that can be activated by in vitro activation and fragmentation treatments, resulting in mature oocytes, and giving rise to successful pregnancies and healthy children.

This aspect represents one of the most clinically relevant findings of our study and opens new avenues of research for developing treatment for women with POI, who have a spontaneous pregnancy rate lower than 5%246, and for whom oocyte donation is the only current clinical option.