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chromosomal abnormality
An alteration in the number or threedimensional structure of chromosomes, usually caused by errors during cell division in the intrauterine stage. It includes the loss (deletion), gain (duplication), or exchange of DNA fragments (translocation), modifying the person's overall genetic dosage. 
Grammatical category Noun
Field Genetics
Level of specialization High
Definition source Propia
Variants
Synonym
chromosomal anomaly
Formal
chromosomal disorder
Formal
Equivalents

Spanish

alteración cromosómica

Valenciano

alteració cromosòmica
Examples
Risk of having a fetus with a chromosomal disorder is increased for most couples who have had a previous fetus or infant with a chromosomal disorder (recognized or missed), except for a few specific types (eg, 45,X; triploidy; de novo chromosomal rearrangements).
Asymptomatic parental chromosomal disorders (eg, balanced abnormalities) such as certain translocations and inversions (no disruption of a gene and no genetic material lost or added) may not be suspected.
Collocations
WITH ADJECTIVES
parental | fetal || asymptomatic || structural chromosomal disorder
WITH VERBS
suggest || increase || have a chromosomal disorder